MLB PICKS

MLB Picks for May 16

ParlayLab's methodology engine grades the Saturday, May 16, 2026 MLB slate against the market. 15 games with 5 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

Toronto Blue Jays at Detroit Tigers

1:10 PM ET

Blue Jays (12-15) visit the Tigers (12-15). Probable starters: M. Fluharty (4.58) for Blue Jays, C. Mize (2.47) for Tigers. Weather at first pitch: 72°F.

Pitchers

TORM. Fluharty (4.58)

DETC. Mize (2.47)

FanDuel lines

MLTOR -102 · DET -116

RL-1.5

TotalO/U 8.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

AZ at Colorado Rockies

3:10 PM ET

AZ (10-13) visit the Rockies (10-16). Probable starters: E. Rodriguez (2.24) for AZ, T. Sugano (3.86) for Rockies. Weather at first pitch: 72°F.

Pitchers

AZE. Rodriguez (2.24)

COLT. Sugano (3.86)

FanDuel lines

MLAZ -142 · COL +120

RL-1.5

TotalO/U 11.5

ParlayLab pick

LOW

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Miami Marlins at Tampa Bay Rays

4:10 PM ET

Marlins (11-14) visit the Rays (19-7). Probable starters: S. Alcantara (4.00) for Marlins, N. Martinez (1.51) for Rays. Dome — no weather impact.

Pitchers

MIAS. Alcantara (4.00)

TBN. Martinez (1.51)

FanDuel lines

MLMIA +114 · TB -134

RL+1.5

TotalO/U 7.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Texas Rangers at Houston Astros

7:10 PM ET

Rangers (11-14) visit the Astros (9-16). Probable starters: J. deGrom (3.86) for Rangers, K. Teng (2.19) for Astros. Dome — no weather impact.

Pitchers

TEXJ. deGrom (3.86)

HOUK. Teng (2.19)

FanDuel lines

MLTEX -144 · HOU +122

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Chicago Cubs at Chicago White Sox

7:10 PM ET

Cubs (20-6) visit the White Sox (15-10). Probable starters: J. Taillon (5.20) for Cubs, D. Martin (2.00) for White Sox. Weather at first pitch: 82°F.

Pitchers

CHCJ. Taillon (5.20)

CWSD. Martin (2.00)

FanDuel lines

MLCHC -108 · CWS -108

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Milwaukee Brewers at Minnesota Twins

7:10 PM ET

Brewers (16-9) visit the Twins (8-18). Probable starters: L. Henderson (3.50) for Brewers, C. Prielipp (4.03) for Twins. Weather at first pitch: 77°F.

Pitchers

MILL. Henderson (3.50)

MINC. Prielipp (4.03)

FanDuel lines

MLMIL -130 · MIN +110

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Boston Red Sox at Atlanta Braves

7:15 PM ET

Red Sox (12-14) visit the Braves (18-7). Probable starters: P. Tolle (2.27) for Red Sox, B. Elder (1.97) for Braves. Weather at first pitch: 84°F.

Pitchers

BOSP. Tolle (2.27)

ATLB. Elder (1.97)

FanDuel lines

MLBOS +102 · ATL -120

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

New York Yankees at New York Mets

7:15 PM ET

Yankees (17-9) visit the Mets (10-14). Probable starters: C. Rodón (4.15) for Yankees, H. Brazobán (1.73) for Mets. Weather at first pitch: 79°F.

Pitchers

NYYC. Rodón (4.15)

NYMH. Brazobán (1.73)

FanDuel lines

MLNYY -122 · NYM +104

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

San Francisco Giants at Athletics

9:40 PM ET

Giants (11-14) visit the Athletics (14-12). Probable starters: T. McDonald (4.76) for Giants, L. Severino (4.23) for Athletics. Weather at first pitch: 58°F.

Pitchers

SFT. McDonald (4.76)

ATHL. Severino (4.23)

FanDuel lines

MLSF +114 · ATH -134

RL+1.5

TotalO/U 9.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.