MLB PICKS

MLB Picks for May 6

ParlayLab's methodology engine grades the Wednesday, May 6, 2026 MLB slate against the market. 15 games with 9 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

Toronto Blue Jays at Tampa Bay Rays

1:10 PM ET

Blue Jays (9-11) visit the Rays (14-5). Probable starters: P. Corbin (3.86) for Blue Jays, S. McClanahan (2.52) for Rays. Dome — no weather impact.

Pitchers

TORP. Corbin (3.86)

TBS. McClanahan (2.52)

FanDuel lines

MLTOR +114 · TB -134

RL+1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Los Angeles Dodgers at Houston Astros

2:10 PM ET

Dodgers (9-9) visit the Astros (6-11). Probable starters: T. Glasnow (2.56) for Dodgers, L. McCullers Jr. (6.86) for Astros. Dome — no weather impact.

Pitchers

LADT. Glasnow (2.56)

HOUL. McCullers Jr. (6.86)

FanDuel lines

MLLAD -215 · HOU +180

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Boston Red Sox at Detroit Tigers

6:40 PM ET

Red Sox (9-10) visit the Tigers (10-10). Probable starters: S. Gray (3.27) for Red Sox, J. Flaherty (5.81) for Tigers. Weather at first pitch: 53°F.

Pitchers

BOSS. Gray (3.27)

DETJ. Flaherty (5.81)

FanDuel lines

MLBOS -108 · DET -108

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Athletics at Philadelphia Phillies

6:40 PM ET

Athletics (9-9) visit the Phillies (7-11). Probable starters: J. Springs (4.11) for Athletics, Z. Wheeler (1.67) for Phillies. Weather at first pitch: 66°F.

Pitchers

ATHJ. Springs (4.11)

PHIZ. Wheeler (1.67)

FanDuel lines

MLATH +140 · PHI -166

RL+1.5

TotalO/U 8.5

ParlayLab pick

LOW

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Baltimore Orioles at Miami Marlins

6:40 PM ET

Orioles (6-11) visit the Marlins (7-10). Probable starters: B. Young (3.47) for Orioles, E. Pérez (4.91) for Marlins. Dome — no weather impact.

Pitchers

BALB. Young (3.47)

MIAE. Pérez (4.91)

FanDuel lines

MLBAL +110 · MIA -130

RL+1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Texas Rangers at New York Yankees

7:05 PM ET

Rangers (7-10) visit the Yankees (15-3). Probable starters: N. Eovaldi (3.65) for Rangers, W. Warren (3.55) for Yankees. Weather at first pitch: 63°F.

Pitchers

TEXN. Eovaldi (3.65)

NYYW. Warren (3.55)

FanDuel lines

MLTEX +146 · NYY -174

RL+1.5

TotalO/U 8.5

ParlayLab pick

MED

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

New York Mets at Colorado Rockies

9:20 PM ET

Mets (6-10) visit the Rockies (7-11). Probable starters: F. Peralta (3.52) for Mets, M. Lorenzen (7.21) for Rockies. Weather at first pitch: 37°F.

Pitchers

NYMF. Peralta (3.52)

COLM. Lorenzen (7.21)

FanDuel lines

MLNYM -158 · COL +134

RL-1.5

TotalO/U 9.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Pittsburgh Pirates at AZ

9:40 PM ET

Pirates (9-9) visit the AZ (6-9). Probable starters: P. Skenes (3.00) for Pirates, M. Soroka (3.27) for AZ. Weather at first pitch: 57°F.

Pitchers

PITP. Skenes (3.00)

AZM. Soroka (3.27)

FanDuel lines

MLPIT -132 · AZ +112

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.