MLB PICKS

MLB Picks for May 6

ParlayLab's methodology engine grades the Wednesday, May 6, 2026 MLB slate against the market. 15 games on the board — moneyline, run line, total, and player props. The full pick selections are available with Pro.

Toronto Blue Jays at Tampa Bay Rays

1:10 PM ET

Blue Jays (16-20) visit the Rays (23-12). Probable starters: P. Corbin (4.73) for Blue Jays, S. McClanahan (3.10) for Rays. Dome — no weather impact.

Pitchers

TORP. Corbin (4.73)

TBS. McClanahan (3.10)

FanDuel lines

MLTOR · TB

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Los Angeles Dodgers at Houston Astros

2:10 PM ET

Dodgers (22-14) visit the Astros (15-22). Probable starters: T. Glasnow (3.02) for Dodgers, L. McCullers Jr. (6.86) for Astros. Dome — no weather impact.

Pitchers

LADT. Glasnow (3.02)

HOUL. McCullers Jr. (6.86)

FanDuel lines

MLLAD · HOU

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Chicago White Sox at Los Angeles Angels

4:07 PM ET

White Sox (17-19) visit the Angels (14-23). Probable starters: N. Schultz (5.82) for White Sox, W. Ureña (2.94) for Angels. Weather at first pitch: 72°F, 10 mph wind.

Pitchers

CWSN. Schultz (5.82)

LAAW. Ureña (2.94)

FanDuel lines

MLCWS · LAA

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Boston Red Sox at Detroit Tigers

6:40 PM ET

Red Sox (15-21) visit the Tigers (18-19). Probable starters: S. Gray (2.79) for Red Sox, J. Flaherty (4.48) for Tigers. Weather at first pitch: 53°F, 7 mph wind.

Pitchers

BOSS. Gray (2.79)

DETJ. Flaherty (4.48)

FanDuel lines

MLBOS · DET

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Athletics at Philadelphia Phillies

6:40 PM ET

Athletics (18-17) visit the Phillies (16-20). Probable starters: J. Springs (6.08) for Athletics, Z. Wheeler (3.40) for Phillies. Weather at first pitch: 66°F, 9 mph wind.

Pitchers

ATHJ. Springs (6.08)

PHIZ. Wheeler (3.40)

FanDuel lines

MLATH · PHI

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Baltimore Orioles at Miami Marlins

6:40 PM ET

Orioles (16-20) visit the Marlins (16-20). Probable starters: B. Young (3.50) for Orioles, E. Pérez (3.17) for Marlins. Dome — no weather impact.

Pitchers

BALB. Young (3.50)

MIAE. Pérez (3.17)

FanDuel lines

MLBAL · MIA

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Texas Rangers at New York Yankees

7:05 PM ET

Rangers (16-19) visit the Yankees (25-11). Probable starters: N. Eovaldi (4.31) for Rangers, W. Warren (4.39) for Yankees. Weather at first pitch: 63°F, 5 mph wind.

Pitchers

TEXN. Eovaldi (4.31)

NYYW. Warren (4.39)

FanDuel lines

MLTEX · NYY

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cincinnati Reds at Chicago Cubs

7:40 PM ET

Reds (20-16) visit the Cubs (24-12). Probable starters: B. Singer (4.72) for Reds, C. Rea (4.67) for Cubs. Weather at first pitch: 53°F, 12 mph wind.

Pitchers

CINB. Singer (4.72)

CHCC. Rea (4.67)

FanDuel lines

MLCIN · CHC

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

New York Mets at Colorado Rockies

9:20 PM ET

Mets (13-22) visit the Rockies (14-22). Probable starters: F. Peralta (5.11) for Mets, M. Lorenzen (6.83) for Rockies. Weather at first pitch: 37°F, 4 mph wind.

Pitchers

NYMF. Peralta (5.11)

COLM. Lorenzen (6.83)

FanDuel lines

MLNYM · COL

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Pittsburgh Pirates at AZ

9:40 PM ET

Pirates (19-17) visit the AZ (17-17). Probable starters: P. Skenes (3.79) for Pirates, M. Soroka (2.93) for AZ. Weather at first pitch: 57°F, 14 mph wind.

Pitchers

PITP. Skenes (3.79)

AZM. Soroka (2.93)

FanDuel lines

MLPIT · AZ

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with Pro. You're charged when you subscribe — cancel anytime.