MLB PICKS

MLB Picks for August 21

ParlayLab's methodology engine grades the Friday, August 21, 2026 MLB slate against the market. 15 games on the board — moneyline, run line, total, and player props. The full pick selections are available with Pro.

Toronto Blue Jays at New York Yankees

7:05 PM ET

Blue Jays (63-66) visit the Yankees (72-55). Probable starters: M. Fluharty (3.38) for Blue Jays, C. Schlittler (2.09) for Yankees. Weather at first pitch: 73°F, 4 mph wind.

Pitchers

TORM. Fluharty (3.38)

NYYC. Schlittler (2.09)

FanDuel lines

MLTOR +176 · NYY -190

RL+1.5

TotalO/U 7

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Atlanta Braves at Milwaukee Brewers

4:10 PM ET

Braves (75-53) visit the Brewers (78-49). Probable starters: C. Sale (2.06) for Braves, J. Misiorowski (1.73) for Brewers. Dome — no weather impact.

Pitchers

ATLC. Sale (2.06)

MILJ. Misiorowski (1.73)

FanDuel lines

MLATL +126 · MIL -138

RL+1.5

TotalO/U 5.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Tampa Bay Rays at Baltimore Orioles

7:15 PM ET

Rays (76-51) visit the Orioles (61-67). Probable starters: F. Peralta (5.11) for Rays, T. Rogers (4.38) for Orioles. Weather at first pitch: 78°F, 6 mph wind.

Pitchers

TBF. Peralta (5.11)

BALT. Rogers (4.38)

FanDuel lines

MLTB +106 · BAL -116

RL+1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

New York Mets at Chicago White Sox

7:40 PM ET

Mets (58-70) visit the White Sox (66-61). Probable starters: S. Manaea (4.70) for Mets, S. Burke (3.32) for White Sox. Weather at first pitch: 74°F, 4 mph wind.

Pitchers

NYMS. Manaea (4.70)

CWSS. Burke (3.32)

FanDuel lines

MLNYM +114 · CWS -124

RL+1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Detroit Tigers at Kansas City Royals

8:10 PM ET

Tigers (61-66) visit the Royals (55-73). Probable starters: T. Melton (2.20) for Tigers, N. Cameron (3.98) for Royals. Weather at first pitch: 85°F, 8 mph wind.

Pitchers

DETT. Melton (2.20)

KCN. Cameron (3.98)

FanDuel lines

MLDET +100 · KC -108

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Athletics at Houston Astros

8:10 PM ET

Athletics (49-79) visit the Astros (64-64). Probable starters: J. Ginn (3.60) for Athletics, H. Wesneski (3.18) for Astros. Dome — no weather impact.

Pitchers

ATHJ. Ginn (3.60)

HOUH. Wesneski (3.18)

FanDuel lines

MLATH +162 · HOU -174

RL+1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cleveland Guardians at Colorado Rockies

8:40 PM ET

Guardians (62-66) visit the Rockies (50-76). Probable starters: J. Cantillo (3.70) for Guardians, T. Gordon (5.18) for Rockies. Weather at first pitch: 91°F, 9 mph wind.

Pitchers

CLEJ. Cantillo (3.70)

COLT. Gordon (5.18)

FanDuel lines

MLCLE -142 · COL +120

RL-1.5

TotalO/U 11

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cincinnati Reds at AZ

9:40 PM ET

Reds (61-67) visit the AZ (67-61). Probable starters: N. Lodolo (5.24) for Reds, E. Rodriguez (2.50) for AZ. Weather at first pitch: 74°F, 11 mph wind.

Pitchers

CINN. Lodolo (5.24)

AZE. Rodriguez (2.50)

FanDuel lines

MLCIN +152 · AZ -180

RL+1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Minnesota Twins at San Diego Padres

9:40 PM ET

Twins (63-65) visit the Padres (67-60). Probable starters: C. Prielipp (5.57) for Twins, R. Vásquez (4.02) for Padres. Weather at first pitch: 75°F, 5 mph wind.

Pitchers

MINC. Prielipp (5.57)

SDR. Vásquez (4.02)

FanDuel lines

MLMIN +130 · SD -154

RL+1.5

TotalO/U 8

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Pittsburgh Pirates at Los Angeles Dodgers

10:10 PM ET

Pirates (63-66) visit the Dodgers (75-49). Probable starters: B. Chandler (4.26) for Pirates, Y. Yamamoto (2.56) for Dodgers. Weather at first pitch: 82°F, 5 mph wind.

Pitchers

PITB. Chandler (4.26)

LADY. Yamamoto (2.56)

FanDuel lines

MLPIT +205 · LAD -225

RL+1.5

TotalO/U 8

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Chicago Cubs at Seattle Mariners

10:10 PM ET

Cubs (74-54) visit the Mariners (60-67). Probable starters: M. Boyd (3.99) for Cubs, E. Hancock (3.30) for Mariners. Dome — no weather impact.

Pitchers

CHCM. Boyd (3.99)

SEAE. Hancock (3.30)

FanDuel lines

MLCHC +100 · SEA -108

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with Pro. You're charged when you subscribe — cancel anytime.