MLB PICKS

MLB Picks for June 22

ParlayLab's methodology engine grades the Monday, June 22, 2026 MLB slate against the market. 12 games on the board — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

New York Yankees at Detroit Tigers

6:10 PM ET

Yankees (34-22) visit the Tigers (23-34). Probable starters: G. Cole (4.04) for Yankees, F. Valdez (4.29) for Tigers. Weather at first pitch: 72°F, 8 mph wind.

Pitchers

NYYG. Cole (4.04)

DETF. Valdez (4.29)

FanDuel lines

MLNYY -126 · DET +108

RL-1.5

TotalO/U 8.5

ParlayLab pick

HIGH

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Texas Rangers at Miami Marlins

6:40 PM ET

Rangers (27-28) visit the Marlins (31-25). Probable starters: T. Alexander (2.29) for Rangers, T. Phillips (3.28) for Marlins. Dome — no weather impact.

Pitchers

TEXT. Alexander (2.29)

MIAT. Phillips (3.28)

FanDuel lines

MLTEX +110 · MIA -130

RL+1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Houston Astros at Toronto Blue Jays

7:07 PM ET

Astros (27-29) visit the Blue Jays (30-29). Probable starters: H. Brown (3.57) for Astros, D. Cease (2.56) for Blue Jays. Dome — no weather impact.

Pitchers

HOUH. Brown (3.57)

TORD. Cease (2.56)

FanDuel lines

MLHOU +112 · TOR -132

RL+1.5

TotalO/U 7

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Milwaukee Brewers at Cincinnati Reds

7:10 PM ET

Brewers (35-21) visit the Reds (25-29). Probable starters: B. Woodruff (2.59) for Brewers, B. Singer (5.03) for Reds. Weather at first pitch: 70°F, 9 mph wind.

Pitchers

MILB. Woodruff (2.59)

CINB. Singer (5.03)

FanDuel lines

MLMIL -152 · CIN +128

RL-1.5

TotalO/U 9.5

ParlayLab pick

HIGH

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Los Angeles Dodgers at Minnesota Twins

7:40 PM ET

Dodgers (33-23) visit the Twins (24-33). Probable starters: W. Klein (2.41) for Dodgers, Z. Matthews (4.57) for Twins. Weather at first pitch: 75°F, 6 mph wind.

Pitchers

LADW. Klein (2.41)

MINZ. Matthews (4.57)

FanDuel lines

MLLAD -148 · MIN +126

RL-1.5

TotalO/U 9.5

ParlayLab pick

HIGH

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cleveland Guardians at Chicago White Sox

7:40 PM ET

Guardians (29-28) visit the White Sox (31-25). Probable starters: G. Williams (3.89) for Guardians, A. Kay (4.29) for White Sox. Weather at first pitch: 63°F, 11 mph wind.

Pitchers

CLEG. Williams (3.89)

CWSA. Kay (4.29)

FanDuel lines

MLCLE -110 · CWS -106

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

AZ at St. Louis Cardinals

7:45 PM ET

AZ (26-27) visit the Cardinals (30-25). Probable starters: M. Kelly (5.71) for AZ, A. Pallante (3.60) for Cardinals. Weather at first pitch: 70°F, 4 mph wind.

Pitchers

AZM. Kelly (5.71)

STLA. Pallante (3.60)

FanDuel lines

MLAZ +128 · STL -152

RL+1.5

TotalO/U 8.5

ParlayLab pick

HIGH

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Boston Red Sox at Colorado Rockies

8:40 PM ET

Red Sox (24-32) visit the Rockies (23-34). Probable starters: J. Bennett (3.10) for Red Sox, R. Feltner (4.27) for Rockies. Weather at first pitch: 87°F, 10 mph wind.

Pitchers

BOSJ. Bennett (3.10)

COLR. Feltner (4.27)

FanDuel lines

MLBOS -136 · COL +116

RL-1.5

TotalO/U 11.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Baltimore Orioles at Los Angeles Angels

9:38 PM ET

Orioles (26-31) visit the Angels (20-34). Probable starters: K. Bradish (3.75) for Orioles, S. Aldegheri (4.85) for Angels. Weather at first pitch: 72°F, 6 mph wind.

Pitchers

BALK. Bradish (3.75)

LAAS. Aldegheri (4.85)

FanDuel lines

MLBAL -162 · LAA +136

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Atlanta Braves at San Diego Padres

10:10 PM ET

Braves (35-20) visit the Padres (27-27). Probable starters: G. Holmes (3.83) for Braves, M. King (3.52) for Padres. Weather at first pitch: 66°F, 6 mph wind.

Pitchers

ATLG. Holmes (3.83)

SDM. King (3.52)

FanDuel lines

MLATL +100 · SD -118

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.