MLB PICKS

MLB Picks for May 27

ParlayLab's methodology engine grades the Wednesday, May 27, 2026 MLB slate against the market. 15 games with 5 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

Miami Marlins at Toronto Blue Jays

1:07 PM ET

Marlins (17-19) visit the Blue Jays (19-19). Probable starters: E. Pérez (3.84) for Marlins, K. Gausman (4.32) for Blue Jays. Dome — no weather impact.

Pitchers

MIAE. Pérez (3.84)

TORK. Gausman (4.32)

FanDuel lines

MLMIA · TOR

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Seattle Mariners at Athletics

3:05 PM ET

Mariners (18-18) visit the Athletics (18-19). Probable starters: L. Gilbert (3.19) for Mariners, J. Springs (5.79) for Athletics. Weather at first pitch: 72°F.

Pitchers

SEAL. Gilbert (3.19)

ATHJ. Springs (5.79)

FanDuel lines

MLSEA · ATH

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

AZ at San Francisco Giants

3:45 PM ET

AZ (19-15) visit the Giants (15-20). Probable starters: M. Soroka (3.11) for AZ, T. McDonald (5.46) for Giants. Weather at first pitch: 72°F.

Pitchers

AZM. Soroka (3.11)

SFT. McDonald (5.46)

FanDuel lines

MLAZ · SF

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Los Angeles Angels at Detroit Tigers

6:40 PM ET

Angels (10-24) visit the Tigers (13-24). Probable starters: J. Soriano (3.40) for Angels, C. Mize (2.64) for Tigers. Weather at first pitch: 76°F, 11 mph wind.

Pitchers

LAAJ. Soriano (3.40)

DETC. Mize (2.64)

FanDuel lines

MLLAA · DET

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Chicago Cubs at Pittsburgh Pirates

6:40 PM ET

Cubs (20-16) visit the Pirates (18-18). Probable starters: J. Taillon (5.37) for Cubs, B. Chandler (4.82) for Pirates. Weather at first pitch: 75°F, 4 mph wind.

Pitchers

CHCJ. Taillon (5.37)

PITB. Chandler (4.82)

FanDuel lines

MLCHC · PIT

RL

Total

ParlayLab pick

HIGH

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Atlanta Braves at Boston Red Sox

6:45 PM ET

Braves (24-11) visit the Red Sox (16-19). Probable starters: B. Elder (4.01) for Braves, C. Early (3.59) for Red Sox. Weather at first pitch: 84°F, 9 mph wind.

Pitchers

ATLB. Elder (4.01)

BOSC. Early (3.59)

FanDuel lines

MLATL · BOS

RL

Total

ParlayLab pick

HIGH

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cincinnati Reds at New York Mets

7:10 PM ET

Reds (19-16) visit the Mets (14-21). Probable starters: A. Abbott (3.92) for Reds, H. Brazobán (1.73) for Mets. Weather at first pitch: 72°F.

Pitchers

CINA. Abbott (3.92)

NYMH. Brazobán (1.73)

FanDuel lines

MLCIN · NYM

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Minnesota Twins at Chicago White Sox

7:40 PM ET

Twins (15-21) visit the White Sox (20-15). Probable starters: C. Prielipp (4.96) for Twins, D. Sandlin (6.05) for White Sox. Weather at first pitch: 64°F, 10 mph wind.

Pitchers

MINC. Prielipp (4.96)

CWSD. Sandlin (6.05)

FanDuel lines

MLMIN · CWS

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Houston Astros at Texas Rangers

8:05 PM ET

Astros (15-20) visit the Rangers (15-19). Probable starters: M. Burrows (5.58) for Astros, J. deGrom (3.48) for Rangers. Dome — no weather impact.

Pitchers

HOUM. Burrows (5.58)

TEXJ. deGrom (3.48)

FanDuel lines

MLHOU · TEX

RL

Total

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.