MLB PICKS

MLB Picks for May 25

ParlayLab's methodology engine grades the Monday, May 25, 2026 MLB slate against the market. 13 games with 5 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

Chicago Cubs at Pittsburgh Pirates

1:35 PM ET

Cubs (20-14) visit the Pirates (16-18). Probable starters: B. Brown (2.01) for Cubs, C. Mlodzinski (3.76) for Pirates. Weather at first pitch: 72°F.

Pitchers

CHCB. Brown (2.01)

PITC. Mlodzinski (3.76)

FanDuel lines

MLCHC -124 · PIT +106

RL-1.5

TotalO/U 8

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Tampa Bay Rays at Baltimore Orioles

1:35 PM ET

Rays (24-9) visit the Orioles (13-20). Probable starters: S. McClanahan (2.52) for Rays, K. Bradish (3.86) for Orioles. Weather at first pitch: 70°F.

Pitchers

TBS. McClanahan (2.52)

BALK. Bradish (3.86)

FanDuel lines

MLTB -110 · BAL -106

RL-1.5

TotalO/U 7.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Minnesota Twins at Chicago White Sox

2:10 PM ET

Twins (14-20) visit the White Sox (19-14). Probable starters: Z. Matthews (2.37) for Twins, A. Kay (3.96) for White Sox. Weather at first pitch: 72°F.

Pitchers

MINZ. Matthews (2.37)

CWSA. Kay (3.96)

FanDuel lines

MLMIN -110 · CWS -106

RL-1.5

TotalO/U 8.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

St. Louis Cardinals at Milwaukee Brewers

2:10 PM ET

Cardinals (19-14) visit the Brewers (21-12). Probable starters: M. Liberatore (4.76) for Cardinals, J. Misiorowski (1.83) for Brewers. Dome — no weather impact.

Pitchers

STLM. Liberatore (4.76)

MILJ. Misiorowski (1.83)

FanDuel lines

MLSTL +184 · MIL -220

RL+1.5

TotalO/U 7.5

ParlayLab pick

MED

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cincinnati Reds at New York Mets

4:10 PM ET

Reds (17-16) visit the Mets (14-19). Probable starters: N. Lodolo (5.57) for Reds, N. McLean (4.40) for Mets. Weather at first pitch: 72°F.

Pitchers

CINN. Lodolo (5.57)

NYMN. McLean (4.40)

FanDuel lines

MLCIN +118 · NYM -138

RL+1.5

TotalO/U 7.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

AZ at San Francisco Giants

5:05 PM ET

AZ (17-15) visit the Giants (15-18). Probable starters: M. Kelly (5.25) for AZ, L. Roupp (3.30) for Giants. Weather at first pitch: 72°F.

Pitchers

AZM. Kelly (5.25)

SFL. Roupp (3.30)

FanDuel lines

MLAZ +114 · SF -134

RL+1.5

TotalO/U 7.5

ParlayLab pick

MED

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Houston Astros at Texas Rangers

7:05 PM ET

Astros (14-19) visit the Rangers (14-18). Probable starters: T. Imai (6.17) for Astros, K. Rocker (3.96) for Rangers. Dome — no weather impact.

Pitchers

HOUT. Imai (6.17)

TEXK. Rocker (3.96)

FanDuel lines

MLHOU +102 · TEX -120

RL+1.5

TotalO/U 8

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Miami Marlins at Toronto Blue Jays

7:07 PM ET

Marlins (16-18) visit the Blue Jays (18-18). Probable starters: J. Junk (4.81) for Marlins, T. Yesavage (2.25) for Blue Jays. Dome — no weather impact.

Pitchers

MIAJ. Junk (4.81)

TORT. Yesavage (2.25)

FanDuel lines

MLMIA +128 · TOR -152

RL+1.5

TotalO/U 7.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Seattle Mariners at Athletics

9:40 PM ET

Mariners (16-18) visit the Athletics (18-17). Probable starters: L. Castillo (6.41) for Mariners, A. Civale (3.31) for Athletics. Weather at first pitch: 72°F.

Pitchers

SEAL. Castillo (6.41)

ATHA. Civale (3.31)

FanDuel lines

MLSEA -118 · ATH +100

RL-1.5

TotalO/U 9.5

ParlayLab pick

HIGH

HIGH edge

ML / RL / O-U projection

Unlock with Pro

3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.