MLB PICKS

MLB Picks for May 25

ParlayLab's methodology engine grades the Monday, May 25, 2026 MLB slate against the market. 13 games with 3 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

Chicago Cubs at Pittsburgh Pirates

1:35 PM ET

Cubs (20-14) visit the Pirates (16-18). Probable starters: B. Brown (1.74) for Cubs, C. Mlodzinski (3.76) for Pirates. Weather at first pitch: 72°F.

Pitchers

CHCB. Brown (1.74)

PITC. Mlodzinski (3.76)

FanDuel lines

MLCHC · PIT

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Tampa Bay Rays at Baltimore Orioles

1:35 PM ET

Rays (24-9) visit the Orioles (13-20). Probable starters: S. McClanahan (3.05) for Rays, K. Bradish (3.75) for Orioles. Weather at first pitch: 70°F, 1 mph wind.

Pitchers

TBS. McClanahan (3.05)

BALK. Bradish (3.75)

FanDuel lines

MLTB · BAL

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

St. Louis Cardinals at Milwaukee Brewers

2:10 PM ET

Cardinals (19-14) visit the Brewers (21-12). Probable starters: M. Liberatore (5.34) for Cardinals, J. Misiorowski (1.47) for Brewers. Dome — no weather impact.

Pitchers

STLM. Liberatore (5.34)

MILJ. Misiorowski (1.47)

FanDuel lines

MLSTL · MIL

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Cincinnati Reds at New York Mets

4:10 PM ET

Reds (17-16) visit the Mets (14-19). Probable starters: N. Lodolo (4.68) for Reds, N. McLean (3.73) for Mets. Weather at first pitch: 72°F.

Pitchers

CINN. Lodolo (4.68)

NYMN. McLean (3.73)

FanDuel lines

MLCIN · NYM

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

AZ at San Francisco Giants

5:05 PM ET

AZ (17-15) visit the Giants (15-18). Probable starters: M. Kelly (5.71) for AZ, L. Roupp (4.55) for Giants. Weather at first pitch: 72°F.

Pitchers

AZM. Kelly (5.71)

SFL. Roupp (4.55)

FanDuel lines

MLAZ · SF

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Houston Astros at Texas Rangers

7:05 PM ET

Astros (14-19) visit the Rangers (14-18). Probable starters: T. Imai (6.06) for Astros, K. Rocker (3.95) for Rangers. Dome — no weather impact.

Pitchers

HOUT. Imai (6.06)

TEXK. Rocker (3.95)

FanDuel lines

MLHOU · TEX

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Miami Marlins at Toronto Blue Jays

7:07 PM ET

Marlins (16-18) visit the Blue Jays (18-18). Probable starters: J. Junk (4.80) for Marlins, T. Yesavage (3.31) for Blue Jays. Dome — no weather impact.

Pitchers

MIAJ. Junk (4.80)

TORT. Yesavage (3.31)

FanDuel lines

MLMIA · TOR

RL

Total

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Seattle Mariners at Athletics

9:40 PM ET

Mariners (16-18) visit the Athletics (18-17). Probable starters: L. Castillo (4.79) for Mariners, A. Civale (4.92) for Athletics. Weather at first pitch: 72°F.

Pitchers

SEAL. Castillo (4.79)

ATHA. Civale (4.92)

FanDuel lines

MLSEA · ATH

RL

Total

ParlayLab pick

HIGH

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.