MLB PICKS
ParlayLab's methodology engine grades the Friday, May 22, 2026 MLB slate against the market. 14 games with 5 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.
Astros (11-19) visit the Cubs (20-11). Probable starters: S. Arrighetti (3.81) for Astros, J. Taillon (5.37) for Cubs. Weather at first pitch: 61°F, 11 mph wind.
Pitchers
HOUS. Arrighetti (3.81)
CHCJ. Taillon (5.37)
FanDuel lines
MLHOU — · CHC —
RL—
Total—
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Guardians (19-13) visit the Phillies (15-16). Probable starters: G. Williams (3.89) for Guardians, C. Sánchez (2.00) for Phillies. Weather at first pitch: 58°F, 5 mph wind.
Pitchers
CLEG. Williams (3.89)
PHIC. Sánchez (2.00)
FanDuel lines
MLCLE — · PHI —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rays (23-8) visit the Yankees (19-13). Probable starters: N. Martinez (2.61) for Rays, G. Cole (4.04) for Yankees. Weather at first pitch: 72°F.
Pitchers
TBN. Martinez (2.61)
NYYG. Cole (4.04)
FanDuel lines
MLTB — · NYY —
RL—
Total—
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Pirates (15-16) visit the Blue Jays (16-17). Probable starters: B. Chandler (4.62) for Pirates, K. Gausman (4.19) for Blue Jays. Dome — no weather impact.
Pitchers
PITB. Chandler (4.62)
TORK. Gausman (4.19)
FanDuel lines
MLPIT — · TOR —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Twins (11-20) visit the Red Sox (16-15). Probable starters: C. Prielipp (4.96) for Twins, P. Tolle (3.39) for Red Sox. Weather at first pitch: 61°F, 5 mph wind.
Pitchers
MINC. Prielipp (4.96)
BOSP. Tolle (3.39)
FanDuel lines
MLMIN — · BOS —
RL—
Total—
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mets (14-16) visit the Marlins (13-18). Probable starters: T. Myers (4.05) for Mets, E. Pérez (4.21) for Marlins. Dome — no weather impact.
Pitchers
NYMT. Myers (4.05)
MIAE. Pérez (4.21)
FanDuel lines
MLNYM — · MIA —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Tigers (12-21) visit the Orioles (11-19). Probable starters: J. Flaherty (4.60) for Tigers, K. Akin (5.68) for Orioles. Weather at first pitch: 55°F, 9 mph wind.
Pitchers
DETJ. Flaherty (4.60)
BALK. Akin (5.68)
FanDuel lines
MLDET — · BAL —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Nationals (16-17) visit the Braves (22-9). Probable starters: R. Lovelady (3.86) for Nationals, B. Elder (4.01) for Braves. Weather at first pitch: 77°F, 9 mph wind.
Pitchers
WSHR. Lovelady (3.86)
ATLB. Elder (4.01)
FanDuel lines
MLWSH — · ATL —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mariners (15-16) visit the Royals (12-19). Probable starters: L. Gilbert (3.42) for Mariners, N. Cameron (4.95) for Royals. Weather at first pitch: 72°F.
Pitchers
SEAL. Gilbert (3.42)
KCN. Cameron (4.95)
FanDuel lines
MLSEA — · KC —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Dodgers (18-13) visit the Brewers (20-10). Probable starters: J. Wrobleski (2.80) for Dodgers, L. Henderson (2.74) for Brewers. Dome — no weather impact.
Pitchers
LADJ. Wrobleski (2.80)
MILL. Henderson (2.74)
FanDuel lines
MLLAD — · MIL —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rangers (14-16) visit the Angels (7-24). Probable starters: J. deGrom (3.48) for Rangers, G. Rodriguez (8.06) for Angels. Weather at first pitch: 72°F.
Pitchers
TEXJ. deGrom (3.48)
LAAG. Rodriguez (8.06)
FanDuel lines
MLTEX — · LAA —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rockies (12-20) visit the AZ (15-14). Probable starters: T. Sugano (4.80) for Rockies, M. Soroka (3.11) for AZ. Weather at first pitch: 58°F, 18 mph wind.
Pitchers
COLT. Sugano (4.80)
AZM. Soroka (3.11)
FanDuel lines
MLCOL — · AZ —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Athletics (17-15) visit the Padres (17-13). Probable starters: J. Springs (5.79) for Athletics, W. Buehler (4.61) for Padres. Weather at first pitch: 65°F, 6 mph wind.
Pitchers
ATHJ. Springs (5.79)
SDW. Buehler (4.61)
FanDuel lines
MLATH — · SD —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
White Sox (18-12) visit the Giants (13-17). Probable starters: D. Martin (3.08) for White Sox, T. McDonald (4.42) for Giants. Weather at first pitch: 72°F.
Pitchers
CWSD. Martin (3.08)
SFT. McDonald (4.42)
FanDuel lines
MLCWS — · SF —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.
Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.
Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.