MLB PICKS
ParlayLab's methodology engine grades the Friday, May 22, 2026 MLB slate against the market. 14 games with 2 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.
Astros (11-19) visit the Cubs (20-11). Probable starters: S. Arrighetti (1.32) for Astros, J. Taillon (5.20) for Cubs. Weather at first pitch: 61°F.
Pitchers
HOUS. Arrighetti (1.32)
CHCJ. Taillon (5.20)
FanDuel lines
MLHOU +120 · CHC -142
RL+1.5
TotalO/U 7
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Guardians (19-13) visit the Phillies (15-16). Probable starters: G. Williams (3.25) for Guardians, C. Sánchez (1.62) for Phillies. Weather at first pitch: 58°F.
Pitchers
CLEG. Williams (3.25)
PHIC. Sánchez (1.62)
FanDuel lines
MLCLE +150 · PHI -178
RL+1.5
TotalO/U 6.5
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rays (23-8) visit the Yankees (19-13). Probable starters: N. Martinez (1.51) for Rays, G. Cole (0.00) for Yankees. Weather at first pitch: 72°F.
Pitchers
TBN. Martinez (1.51)
NYYG. Cole (0.00)
FanDuel lines
MLTB +126 · NYY -148
RL+1.5
TotalO/U 7.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Pirates (15-16) visit the Blue Jays (16-17). Probable starters: B. Chandler (4.60) for Pirates, K. Gausman (3.23) for Blue Jays. Dome — no weather impact.
Pitchers
PITB. Chandler (4.60)
TORK. Gausman (3.23)
FanDuel lines
MLPIT +138 · TOR -164
RL+1.5
TotalO/U 8
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Twins (11-20) visit the Red Sox (16-15). Probable starters: C. Prielipp (4.03) for Twins, P. Tolle (2.27) for Red Sox. Weather at first pitch: 61°F.
Pitchers
MINC. Prielipp (4.03)
BOSP. Tolle (2.27)
FanDuel lines
MLMIN +126 · BOS -148
RL+1.5
TotalO/U 7.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mets (14-16) visit the Marlins (13-18). Probable starters: T. Myers (3.41) for Mets, E. Pérez (4.91) for Marlins. Dome — no weather impact.
Pitchers
NYMT. Myers (3.41)
MIAE. Pérez (4.91)
FanDuel lines
MLNYM -104 · MIA -112
RL-1.5
TotalO/U 7.5
ParlayLab pick
MEDHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Tigers (12-21) visit the Orioles (11-19). Probable starters: J. Flaherty (5.81) for Tigers, K. Akin (10.66) for Orioles. Weather at first pitch: 55°F.
Pitchers
DETJ. Flaherty (5.81)
BALK. Akin (10.66)
FanDuel lines
MLDET +112 · BAL -132
RL+1.5
TotalO/U 8.5
ParlayLab pick
HIGHMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Nationals (16-17) visit the Braves (22-9). Probable starters: R. Lovelady (2.70) for Nationals, B. Elder (1.97) for Braves. Weather at first pitch: 77°F.
Pitchers
WSHR. Lovelady (2.70)
ATLB. Elder (1.97)
FanDuel lines
MLWSH +164 · ATL -196
RL+1.5
TotalO/U 8.5
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mariners (15-16) visit the Royals (12-19). Probable starters: L. Gilbert (4.04) for Mariners, N. Cameron (4.72) for Royals. Weather at first pitch: 72°F.
Pitchers
SEAL. Gilbert (4.04)
KCN. Cameron (4.72)
FanDuel lines
MLSEA -118 · KC +100
RL-1.5
TotalO/U 8
ParlayLab pick
HIGHMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Dodgers (18-13) visit the Brewers (20-10). Probable starters: J. Wrobleski (3.07) for Dodgers, L. Henderson (3.50) for Brewers. Dome — no weather impact.
Pitchers
LADJ. Wrobleski (3.07)
MILL. Henderson (3.50)
FanDuel lines
MLLAD -104 · MIL -112
RL-1.5
TotalO/U 8.5
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rangers (14-16) visit the Angels (7-24). Probable starters: J. deGrom (3.86) for Rangers, G. Rodriguez (7.53) for Angels. Weather at first pitch: 72°F.
Pitchers
TEXJ. deGrom (3.86)
LAAG. Rodriguez (7.53)
FanDuel lines
MLTEX -162 · LAA +136
RL-1.5
TotalO/U 7.5
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rockies (12-20) visit the AZ (15-14). Probable starters: T. Sugano (3.86) for Rockies, M. Soroka (3.27) for AZ. Weather at first pitch: 58°F.
Pitchers
COLT. Sugano (3.86)
AZM. Soroka (3.27)
FanDuel lines
MLCOL +184 · AZ -220
RL+1.5
TotalO/U 9
ParlayLab pick
HIGHMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Athletics (17-15) visit the Padres (17-13). Probable starters: J. Springs (4.11) for Athletics, W. Buehler (5.05) for Padres. Weather at first pitch: 65°F.
Pitchers
ATHJ. Springs (4.11)
SDW. Buehler (5.05)
FanDuel lines
MLATH +106 · SD -124
RL-1.5
TotalO/U 7.5
ParlayLab pick
HIGHMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
White Sox (18-12) visit the Giants (13-17). Probable starters: D. Martin (2.00) for White Sox, T. McDonald (4.76) for Giants. Weather at first pitch: 72°F.
Pitchers
CWSD. Martin (2.00)
SFT. McDonald (4.76)
FanDuel lines
MLCWS -112 · SF -104
RL-1.5
TotalO/U 7.5
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.
Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.
Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.