MLB PICKS
ParlayLab's methodology engine grades the Friday, May 22, 2026 MLB slate against the market. 14 games with 5 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with Pro.
Astros (20-31) visit the Cubs (29-21). Probable starters: S. Arrighetti (4.73) for Astros, J. Taillon (5.96) for Cubs. Weather at first pitch: 61°F, 11 mph wind.
Pitchers
HOUS. Arrighetti (4.73)
CHCJ. Taillon (5.96)
FanDuel lines
MLHOU — · CHC —
RL—
Total—
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Guardians (30-22) visit the Phillies (25-25). Probable starters: G. Williams (3.72) for Guardians, C. Sánchez (2.62) for Phillies. Weather at first pitch: 58°F, 5 mph wind.
Pitchers
CLEG. Williams (3.72)
PHIC. Sánchez (2.62)
FanDuel lines
MLCLE — · PHI —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rays (33-15) visit the Yankees (30-21). Probable starters: N. Martinez (2.93) for Rays, G. Cole (3.19) for Yankees. Weather at first pitch: 72°F.
Pitchers
TBN. Martinez (2.93)
NYYG. Cole (3.19)
FanDuel lines
MLTB — · NYY —
RL—
Total—
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Pirates (26-24) visit the Blue Jays (23-27). Probable starters: B. Chandler (4.38) for Pirates, K. Gausman (4.37) for Blue Jays. Dome — no weather impact.
Pitchers
PITB. Chandler (4.38)
TORK. Gausman (4.37)
FanDuel lines
MLPIT — · TOR —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Twins (23-27) visit the Red Sox (22-27). Probable starters: C. Prielipp (5.57) for Twins, P. Tolle (3.09) for Red Sox. Weather at first pitch: 61°F, 5 mph wind.
Pitchers
MINC. Prielipp (5.57)
BOSP. Tolle (3.09)
FanDuel lines
MLMIN — · BOS —
RL—
Total—
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mets (22-28) visit the Marlins (22-29). Probable starters: T. Myers (4.05) for Mets, E. Pérez (3.17) for Marlins. Dome — no weather impact.
Pitchers
NYMT. Myers (4.05)
MIAE. Pérez (3.17)
FanDuel lines
MLNYM — · MIA —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Tigers (20-31) visit the Orioles (21-29). Probable starters: J. Flaherty (4.48) for Tigers, K. Akin (5.68) for Orioles. Weather at first pitch: 55°F, 9 mph wind.
Pitchers
DETJ. Flaherty (4.48)
BALK. Akin (5.68)
FanDuel lines
MLDET — · BAL —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Nationals (25-26) visit the Braves (35-16). Probable starters: R. Lovelady (3.86) for Nationals, B. Elder (3.95) for Braves. Weather at first pitch: 77°F, 9 mph wind.
Pitchers
WSHR. Lovelady (3.86)
ATLB. Elder (3.95)
FanDuel lines
MLWSH — · ATL —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mariners (24-27) visit the Royals (20-30). Probable starters: L. Gilbert (3.36) for Mariners, N. Cameron (4.02) for Royals. Weather at first pitch: 72°F.
Pitchers
SEAL. Gilbert (3.36)
KCN. Cameron (4.02)
FanDuel lines
MLSEA — · KC —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Dodgers (31-19) visit the Brewers (29-18). Probable starters: J. Wrobleski (3.44) for Dodgers, L. Henderson (2.60) for Brewers. Dome — no weather impact.
Pitchers
LADJ. Wrobleski (3.44)
MILL. Henderson (2.60)
FanDuel lines
MLLAD — · MIL —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rangers (24-25) visit the Angels (17-34). Probable starters: J. deGrom (4.21) for Rangers, G. Rodriguez (6.03) for Angels. Weather at first pitch: 72°F.
Pitchers
TEXJ. deGrom (4.21)
LAAG. Rodriguez (6.03)
FanDuel lines
MLTEX — · LAA —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rockies (19-32) visit the AZ (26-23). Probable starters: T. Sugano (4.96) for Rockies, M. Soroka (2.93) for AZ. Weather at first pitch: 58°F, 18 mph wind.
Pitchers
COLT. Sugano (4.96)
AZM. Soroka (2.93)
FanDuel lines
MLCOL — · AZ —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Athletics (26-24) visit the Padres (29-20). Probable starters: J. Springs (6.08) for Athletics, W. Buehler (4.63) for Padres. Weather at first pitch: 65°F, 6 mph wind.
Pitchers
ATHJ. Springs (6.08)
SDW. Buehler (4.63)
FanDuel lines
MLATH — · SD —
RL—
Total—
ParlayLab pick
HIGHHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
White Sox (25-24) visit the Giants (20-30). Probable starters: D. Martin (4.17) for White Sox, T. McDonald (5.02) for Giants. Weather at first pitch: 72°F.
Pitchers
CWSD. Martin (4.17)
SFT. McDonald (5.02)
FanDuel lines
MLCWS — · SF —
RL—
Total—
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.
Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.
Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with Pro. You're charged when you subscribe — cancel anytime.