MLB PICKS
ParlayLab's methodology engine grades the Wednesday, July 22, 2026 MLB slate against the market. 17 games with 2 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with Pro.
Pirates (52-49) visit the Yankees (56-44). Probable starters: B. Chandler (4.38) for Pirates, M. Fried (2.81) for Yankees. Weather at first pitch: 86°F, 10 mph wind.
Pitchers
PITB. Chandler (4.38)
NYYM. Fried (2.81)
FanDuel lines
MLPIT +150 · NYY -178
RL+1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Orioles (49-52) visit the Red Sox (51-48). Probable starters: D. Kremer (5.22) for Orioles, J. Bennett (3.49) for Red Sox. Weather at first pitch: 82°F, 13 mph wind.
Pitchers
BALD. Kremer (5.22)
BOSJ. Bennett (3.49)
FanDuel lines
MLBAL +120 · BOS -142
RL+1.5
TotalO/U 9.5
ParlayLab pick
LOWHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Giants (42-59) visit the Royals (42-60). Probable starters: L. Roupp (4.34) for Giants, S. Lugo (4.61) for Royals. Weather at first pitch: 82°F, 9 mph wind.
Pitchers
SFL. Roupp (4.34)
KCS. Lugo (4.61)
FanDuel lines
MLSF -130 · KC +110
RL-1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Mets (43-59) visit the Brewers (63-38). Probable starters: C. Scott (3.73) for Mets, L. Henderson (2.60) for Brewers. Dome — no weather impact.
Pitchers
NYMC. Scott (3.73)
MILL. Henderson (2.60)
FanDuel lines
MLNYM +134 · MIL -158
RL+1.5
TotalO/U 7.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Nationals (51-51) visit the Rockies (41-62). Probable starters: C. Cavalli (3.21) for Nationals, G. Hughes (6.61) for Rockies. Weather at first pitch: 93°F, 6 mph wind.
Pitchers
WSHC. Cavalli (3.21)
COLG. Hughes (6.61)
FanDuel lines
MLWSH -146 · COL +124
RL-1.5
TotalO/U 11.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Athletics (43-58) visit the AZ (52-49). Probable starters: G. Jump (4.83) for Athletics, M. Kelly (5.35) for AZ. Weather at first pitch: 79°F, 10 mph wind.
Pitchers
ATHG. Jump (4.83)
AZM. Kelly (5.35)
FanDuel lines
MLATH +116 · AZ -136
RL+1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Reds (46-54) visit the Mariners (51-51). Probable starters: B. Singer (4.72) for Reds, E. Hancock (3.30) for Mariners. Dome — no weather impact.
Pitchers
CINB. Singer (4.72)
SEAE. Hancock (3.30)
FanDuel lines
MLCIN +138 · SEA -164
RL+1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Cardinals (51-49) visit the Angels (41-61). Probable starters: H. Dobbins (3.40) for Cardinals, R. Detmers (3.62) for Angels. Weather at first pitch: 84°F, 7 mph wind.
Pitchers
STLH. Dobbins (3.40)
LAAR. Detmers (3.62)
FanDuel lines
MLSTL +120 · LAA -142
RL+1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Twins (49-53) visit the Guardians (54-48). Probable starters: B. Ober (4.49) for Twins, S. Cecconi (4.60) for Guardians. Weather at first pitch: 70°F, 5 mph wind.
Pitchers
MINB. Ober (4.49)
CLES. Cecconi (4.60)
FanDuel lines
MLMIN +122 · CLE -144
RL+1.5
TotalO/U 8
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Dodgers (64-38) visit the Phillies (56-46). Probable starters: E. Lauer (4.67) for Dodgers, A. Nola (5.12) for Phillies. Weather at first pitch: 79°F, 9 mph wind.
Pitchers
LADE. Lauer (4.67)
PHIA. Nola (5.12)
FanDuel lines
MLLAD -124 · PHI +106
RL-1.5
TotalO/U 9.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Rays (58-42) visit the Blue Jays (46-55). Probable starters: G. Jax (3.63) for Rays, B. Fisher (3.54) for Blue Jays. Dome — no weather impact.
Pitchers
TBG. Jax (3.63)
TORB. Fisher (3.54)
FanDuel lines
MLTB -108 · TOR -108
RL-1.5
TotalO/U 7.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Orioles (49-52) visit the Red Sox (51-48). Probable starters: K. Bradish (3.70) for Orioles, E. Rivera (6.30) for Red Sox. Weather at first pitch: 75°F, 8 mph wind.
Pitchers
BALK. Bradish (3.70)
BOSE. Rivera (6.30)
FanDuel lines
MLBAL +108 · BOS -126
RL+1.5
TotalO/U 9
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Padres (50-51) visit the Braves (58-42). Probable starters: M. King (3.38) for Padres, M. Pérez (3.12) for Braves. Weather at first pitch: 84°F, 8 mph wind.
Pitchers
SDM. King (3.38)
ATLM. Pérez (3.12)
FanDuel lines
MLSD -108 · ATL -108
RL-1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
White Sox (53-47) visit the Rangers (51-50). Probable starters: A. Kay (3.96) for White Sox, T. Alexander (3.45) for Rangers. Dome — no weather impact.
Pitchers
CWSA. Kay (3.96)
TEXT. Alexander (3.45)
FanDuel lines
MLCWS -122 · TEX +104
RL-1.5
TotalO/U 8.5
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Tigers (47-54) visit the Cubs (57-44). Probable starters: K. Montero (3.30) for Tigers, C. Rea (4.67) for Cubs. Weather at first pitch: 70°F, 9 mph wind.
Pitchers
DETK. Montero (3.30)
CHCC. Rea (4.67)
FanDuel lines
MLDET +106 · CHC -124
RL+1.5
TotalO/U 8
ParlayLab pick
LOWMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Marlins (52-50) visit the Astros (49-54). Probable starters: S. Alcantara (3.38) for Marlins, P. Lambert (3.68) for Astros. Dome — no weather impact.
Pitchers
MIAS. Alcantara (3.38)
HOUP. Lambert (3.68)
FanDuel lines
MLMIA -106 · HOU -110
RL-1.5
TotalO/U 8
ParlayLab pick
MEDMED edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Pirates (52-49) visit the Yankees (56-44). Probable starters: M. Keller (4.83) for Pirates, G. Cole (3.19) for Yankees. Weather at first pitch: 88°F, 14 mph wind.
Pitchers
PITM. Keller (4.83)
NYYG. Cole (3.19)
FanDuel lines
MLPIT +164 · NYY -196
RL+1.5
TotalO/U 9.5
ParlayLab pick
LOWHIGH edge
ML / RL / O-U projection
3 qualifying picks across moneyline, run line, and totals.
Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.
Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.
Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with Pro. You're charged when you subscribe — cancel anytime.