MLB PICKS

MLB Picks for May 20

ParlayLab's methodology engine grades the Wednesday, May 20, 2026 MLB slate against the market. 15 games with 2 HIGH-confidence picks — moneyline, run line, total, and player props. The full pick selections are available with a free 7-day Pro trial.

Houston Astros at Minnesota Twins

1:40 PM ET

Astros (11-18) visit the Twins (10-20). Probable starters: M. Burrows (5.75) for Astros, J. Ryan (3.02) for Twins. Weather at first pitch: 72°F.

Pitchers

HOUM. Burrows (5.75)

MINJ. Ryan (3.02)

FanDuel lines

MLHOU +120 · MIN -142

RL+1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Texas Rangers at Colorado Rockies

3:10 PM ET

Rangers (13-16) visit the Rockies (12-18). Probable starters: J. Leiter (4.61) for Rangers, K. Freeland (7.04) for Rockies. Weather at first pitch: 72°F.

Pitchers

TEXJ. Leiter (4.61)

COLK. Freeland (7.04)

FanDuel lines

MLTEX -120 · COL +102

RL-1.5

TotalO/U 10

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

San Francisco Giants at AZ

3:40 PM ET

Giants (13-16) visit the AZ (13-14). Probable starters: T. Mahle (6.10) for Giants, M. Kelly (5.25) for AZ. Weather at first pitch: 72°F.

Pitchers

SFT. Mahle (6.10)

AZM. Kelly (5.25)

FanDuel lines

MLSF -106 · AZ -110

RL-1.5

TotalO/U 8.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Chicago White Sox at Seattle Mariners

4:10 PM ET

White Sox (18-11) visit the Mariners (14-16). Probable starters: S. Burke (4.08) for White Sox, E. Hancock (3.07) for Mariners. Dome — no weather impact.

Pitchers

CWSS. Burke (4.08)

SEAE. Hancock (3.07)

FanDuel lines

MLCWS +122 · SEA -144

RL+1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Atlanta Braves at Miami Marlins

6:40 PM ET

Braves (20-9) visit the Marlins (13-16). Probable starters: C. Sale (1.80) for Braves, J. Junk (4.81) for Marlins. Dome — no weather impact.

Pitchers

ATLC. Sale (1.80)

MIAJ. Junk (4.81)

FanDuel lines

MLATL -188 · MIA +158

RL-1.5

TotalO/U 7

ParlayLab pick

HIGH

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

New York Mets at Washington Nationals

6:45 PM ET

Mets (13-15) visit the Nationals (15-16). Probable starters: Z. Thornton (4.35) for Mets, Z. Littell (5.83) for Nationals. Weather at first pitch: 75°F.

Pitchers

NYMZ. Thornton (4.35)

WSHZ. Littell (5.83)

FanDuel lines

MLNYM -130 · WSH +110

RL-1.5

TotalO/U 9.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Toronto Blue Jays at New York Yankees

7:05 PM ET

Blue Jays (14-17) visit the Yankees (19-11). Probable starters: T. Yesavage (2.25) for Blue Jays, C. Schlittler (1.50) for Yankees. Weather at first pitch: 72°F.

Pitchers

TORT. Yesavage (2.25)

NYYC. Schlittler (1.50)

FanDuel lines

MLTOR +146 · NYY -174

RL+1.5

TotalO/U 7.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Milwaukee Brewers at Chicago Cubs

7:40 PM ET

Brewers (19-10) visit the Cubs (20-10). Probable starters: K. Harrison (1.77) for Brewers, E. Cabrera (4.06) for Cubs. Weather at first pitch: 52°F.

Pitchers

MILK. Harrison (1.77)

CHCE. Cabrera (4.06)

FanDuel lines

MLMIL +100 · CHC -118

RL-1.5

TotalO/U 6.5

ParlayLab pick

MED

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Pittsburgh Pirates at St. Louis Cardinals

7:45 PM ET

Pirates (13-16) visit the Cardinals (18-11). Probable starters: C. Mlodzinski (3.76) for Pirates, M. McGreevy (2.40) for Cardinals. Weather at first pitch: 64°F.

Pitchers

PITC. Mlodzinski (3.76)

STLM. McGreevy (2.40)

FanDuel lines

MLPIT -104 · STL -112

RL-1.5

TotalO/U 7.5

ParlayLab pick

LOW

MED edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

Athletics at Los Angeles Angels

9:38 PM ET

Athletics (15-15) visit the Angels (7-22). Probable starters: A. Civale (3.31) for Athletics, J. Kochanowicz (4.55) for Angels. Weather at first pitch: 72°F.

Pitchers

ATHA. Civale (3.31)

LAAJ. Kochanowicz (4.55)

FanDuel lines

MLATH -126 · LAA +108

RL-1.5

TotalO/U 9.5

ParlayLab pick

HIGH

HIGH edge

ML / RL / O-U projection

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3 qualifying picks across moneyline, run line, and totals.

How ParlayLab grades the slate

Our methodology engine projects each MLB game using a market-blended model that combines team-level offense, starting-pitcher form, ballpark factors, weather (wind direction relative to center field, temperature, precipitation), bullpen fatigue, and Statcast contact quality. The engine outputs a moneyline, run-line, and total projection for every matchup and grades each pick HIGH / MED / LOW confidence based on the edge versus the FanDuel line.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-vs-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-vs-line edges show up bright green; weak ones drop to orange or red.

Free users see the top picks for each market per slate plus the per-game matchup context shown above. The full pick selections, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with a Pro trial. No card charged for the first 7 days.