MLB SLATE

MLB Slate for April 21

The slate for Tuesday, April 21, 2026 has 15 games, each with its probable starters, FanDuel lines, weather and ballpark. This slate came before the experimental MLB specialists began on September 30, 2026.

ParlayLab’s blanket moneyline, run-line and total picks were retired on September 30, 2026. MLB selections now come from 13 experimental specialists, decided before first pitch and logged at the price they were recorded at. See the specialists and their records.

Houston Astros at Cleveland Guardians

6:10 PM ET

Astros (9-15) visit the Guardians (13-11). Probable starters: R. Weiss for Astros, P. Messick (2.56) for Guardians.

Pitchers

HOUR. Weiss

CLEP. Messick (2.56)

FanDuel Lines

MLHOU — · CLE —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Cincinnati Reds at Tampa Bay Rays

6:40 PM ET

Reds (15-8) visit the Rays (12-10). Probable starters: C. Burns (2.80) for Reds, S. Matz (5.46) for Rays.

Pitchers

CINC. Burns (2.80)

TBS. Matz (5.46)

FanDuel Lines

MLCIN — · TB —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

St. Louis Cardinals at Miami Marlins

6:40 PM ET

Cardinals (13-9) visit the Marlins (11-12). Probable starters: D. May (4.70) for Cardinals, C. Paddack (6.86) for Marlins.

Pitchers

STLD. May (4.70)

MIAC. Paddack (6.86)

FanDuel Lines

MLSTL — · MIA —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Milwaukee Brewers at Detroit Tigers

6:40 PM ET

Brewers (12-9) visit the Tigers (12-11). Probable starters: K. Harrison (4.25) for Brewers, K. Montero (3.55) for Tigers.

Pitchers

MILK. Harrison (4.25)

DETK. Montero (3.55)

FanDuel Lines

MLMIL — · DET —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Atlanta Braves at Washington Nationals

6:45 PM ET

Braves (16-7) visit the Nationals (10-13). Probable starters: R. López (4.13) for Braves, F. Griffin (3.60) for Nationals.

Pitchers

ATLR. López (4.13)

WSHF. Griffin (3.60)

FanDuel Lines

MLATL — · WSH —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

New York Yankees at Boston Red Sox

6:45 PM ET

Yankees (13-9) visit the Red Sox (9-13). Probable starters: L. Gil for Yankees, C. Early (3.44) for Red Sox.

Pitchers

NYYL. Gil

BOSC. Early (3.44)

FanDuel Lines

MLNYY — · BOS —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Minnesota Twins at New York Mets

7:10 PM ET

Twins (11-11) visit the Mets (7-15). Probable starters: S. Woods Richardson (6.92) for Twins, N. McLean (3.18) for Mets.

Pitchers

MINS. Woods Richardson (6.92)

NYMN. McLean (3.18)

FanDuel Lines

MLMIN — · NYM —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Baltimore Orioles at Kansas City Royals

7:40 PM ET

Orioles (11-12) visit the Royals (7-16). Probable starters: S. Baz (4.11) for Orioles, K. Bubic (3.50) for Royals.

Pitchers

BALS. Baz (4.11)

KCK. Bubic (3.50)

FanDuel Lines

MLBAL — · KC —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Philadelphia Phillies at Chicago Cubs

7:40 PM ET

Phillies (8-14) visit the Cubs (13-9). Probable starters: J. Luzardo (2.86) for Phillies, S. Imanaga (3.74) for Cubs.

Pitchers

PHIJ. Luzardo (2.86)

CHCS. Imanaga (3.74)

FanDuel Lines

MLPHI — · CHC —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Pittsburgh Pirates at Texas Rangers

8:05 PM ET

Pirates (13-9) visit the Rangers (11-11). Probable starters: C. Mlodzinski (3.79) for Pirates, K. Rocker (4.47) for Rangers.

Pitchers

PITC. Mlodzinski (3.79)

TEXK. Rocker (4.47)

FanDuel Lines

MLPIT — · TEX —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

San Diego Padres at Colorado Rockies

8:40 PM ET

Padres (15-7) visit the Rockies (9-14). Probable starters: R. Vásquez (4.01) for Padres, J. Herget for Rockies.

Pitchers

SDR. Vásquez (4.01)

COLJ. Herget

FanDuel Lines

MLSD — · COL —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Toronto Blue Jays at Los Angeles Angels

9:38 PM ET

Blue Jays (9-13) visit the Angels (11-13). Probable starters: P. Corbin (4.73) for Blue Jays, J. Kochanowicz (5.23) for Angels.

Pitchers

TORP. Corbin (4.73)

LAAJ. Kochanowicz (5.23)

FanDuel Lines

MLTOR — · LAA —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Athletics at Seattle Mariners

9:40 PM ET

Athletics (12-11) visit the Mariners (10-14). Probable starters: J. Lopez (5.02) for Athletics, L. Castillo (5.31) for Mariners.

Pitchers

ATHJ. Lopez (5.02)

SEAL. Castillo (5.31)

FanDuel Lines

MLATH — · SEA —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Chicago White Sox at Arizona Diamondbacks

9:40 PM ET

White Sox (8-14) visit the Diamondbacks (13-9). Probable starters: S. Burke (3.34) for White Sox, M. Kelly (5.00) for Diamondbacks.

Pitchers

CWSS. Burke (3.34)

AZM. Kelly (5.00)

FanDuel Lines

MLCWS — · AZ —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

Los Angeles Dodgers at San Francisco Giants

9:45 PM ET

Dodgers (16-6) visit the Giants (9-13). Probable starters: Y. Yamamoto (2.53) for Dodgers, L. Roupp (4.00) for Giants.

Pitchers

LADY. Yamamoto (2.53)

SFL. Roupp (4.00)

FanDuel Lines

MLLAD — · SF —

RL—

Total—

MLB Specialists

Experimental

No specialist selection

Before the specialists began on Sep 30, 2026.

Research selections logged before first pitch, not betting-validated.

How ParlayLab Covers the Slate

Every MLB game carries its research: both starting pitchers’ season and recent form, the bullpens, each lineup against the hand it faces, ballpark factors, weather (wind relative to center field, temperature, precipitation), and the FanDuel moneyline, run line and total with their movement since the open.

Game selections come from 13 experimental MLB specialists — eight on the moneyline, two on the run line and three on the under. Each is a fixed rule on season-to-date team or starting-pitcher history, decided in the hour before first pitch and logged at the FanDuel price it was recorded at. They cover regular-season games only. Their historical records are exploratory backtests, not validated profitability and not live results, and a game none of them selects reads “No specialist selection”.

Player props go through a separate Poisson projection layer per stat — hits, home runs, total bases, RBIs, runs scored, hits+runs+RBIs, and pitcher strikeouts. Each prop projection accounts for the batter-versus-pitcher history, recent rolling form, opposing pitcher ERA / WHIP / K%, ballpark-by-handedness factors, and weather. Props with strong projection-versus-line edges show up bright green; weak ones drop to orange or red.

Free users see the slate, the per-game matchup context shown above and the top props. The specialists’ tickets, every prop on the board, the prop filter builder, and the full Game Detail + Player Detail breakdowns unlock with Pro. You're charged when you subscribe — cancel anytime.